Leah Matzat
Building tools to power precision medicine.
With over a decade of experience working across industry, startups, and advisory roles, I help teams build and launch clinical diagnostic products powered by next-generation sequencing platforms. The products I've built have helped deliver genetic results to millions of patients.
My Experience
Senior Director R&D
I spent a decade leading Invitae's, and now Labcorp's, clinical genetic testing laboratory R&D. I launched several market leading clinical genetic tests in hereditary oncology, rare disease, and women's health. As a senior leader with over 15 years of experience in biotechnology and genomic diagnostics, I've built a reputation as a builder, creative problem solver, and people-oriented leader.
My contributions to product development and operational scaling helped grow genetic testing at Invitae from startup phase to a multi-million patient business. I played a key role building the most advanced clinical lab in the world. Our highly integrated lab pioneered the concept of modularized automation work cells to complete discrete sets of lab work as well as utilizing software to drive lab processes and decision making, such as fully automated specimen management, software-to-instrument communication, QC processes, and business process management. As a result, the Invitae lab has the lowest personnel to volume ratio in the industry.
A highlight of my career has been playing a key role in strategic business development and M&A activities to support expansion of Invitae's technology and testing portfolio. I also served as a technical advisor during the sale of Invitae to Labcorp for $239M in 2024.
Some Things I've Built

Invitae Test Portfolio
As a scientist and product development expert, I helped to build and scale the Invitae testing platform to enable results for hundreds of genes to be delivered to patients in a matter of days at a cost of less than $250. I built the world's most advanced genetic testing laboratory infrastructure, used PacBio sequencing for the first time in a clinical lab, and launched the most successful hereditary cancer test of all time.

Clinical Trials Search Platform
A comprehensive platform that helps patients and researchers find relevant clinical trials through personalized search paths at trialexplorer.org. Features condition research, treatment comparison tools, and historical trial outcome analysis to guide informed healthcare decisions.
Get In Touch
Please reach out if you'd like to connect, talk about project ideas, or work together. I look forward to meeting you!